Javier Sancho

Universidad de Zaragoza, Spain

Javier Sancho received the B.S. degree from the University of Zaragoza, Spain (1984), Ph.D. degree from the same university (1988), and postdoctoral fellowship from Cambridge University, UK, from 1989 to 1991. Sancho is a Professor of biochemistry and molecular biology at University of Zaragoza and Deputy Director of the Institute of Biocomputation and Complex Systems Physics. Sancho is a Member of Spanish Society for Biochemistry and Molecular Biology (Spain), Spanish Society for Biophysics (Spain), and Biophysical Society (USA). Sancho received Bruker Award of the Spanish Biophysical Society. Sancho's research interests include the principles of protein stability, folding and binding, and trying to understand the relationship between protein dynamics and function. In their group, they combine wet experiments with computation. Some of our current computational studies try to address the molecular dynamics identification of SNPs involved in conformational diseases, the prediction of local unstable regions of proteins involved in dynamics, and the development of computational aids for protein stabilization, such as the ProtSA server for estimating sequence specific atom accessibilities of proteins in unfolded ensembles. They also investigate protein conformational diseases in order to both understand their molecular causes and to discover pharmacological chaperones that can be developed into new drug therapies. They are currently working in a variety of protein-related diseases, such as phenylketonuria, Alzheimer disease, and type II diabetes, and also in developing novel bug-specific antimicrobials.

Biography Updated on 19 October 2013

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