Mariusz Z. Ratajczak

University of Louisville, USA


M. Ratajczak holds the M.D., Ph.D., and D.S. (h.c.) degrees. He is the Henry and Stella Hoenig Endowed Chair in cancer biology and the Director of the Developmental Biology Research Program at the University of Louisville's James Graham Brown Cancer Center, Ky, USA. Dr. Ratajczak is an internationally known investigator in the field of adult stem cell biology. He has published numerous books and more than 300 peer-reviewed publications and is a frequent speaker at conferences worldwide. For the past 25 years, he has worked to develop new concepts in hematopoietic transplantation biology. Studies include the development of novel strategies for the purging of hematopoietic transplants, protocols to accelerate platelet recovery after transplantation, and novel strategies to enhance both mobilization and engraftment of hematopoietic stem cells. He pioneered studies into the role of innate immunity and complement cascade as a major modulator of the SDF-1-CXCR4 axis in the trafficking of stem cells, elucidated the molecular mechanisms responsible for metastasis of pediatric sarcomas to the bone marrow and recently identified in adult bone marrow and cord blood a population of pluripotent very small embryonic-like stem cells (VSEL). These cells, drawn from adult bone marrow, appear to mimic the ability of stem cells to multiply and develop into other kinds of cells.

Biography Updated on 12 January 2011

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