Fazlul H. Sarkar

Wayne State University School of Medicine, USA

Dr Sarkar is a Professor of Pathology at Karmanos Cancer Center, Wayne State University School of Medicine, Detroit, MI USA with a track-record of cancer research for 30 years. His research is focused on understanding the role of a “master” transcription factor, NF-?B and the regulation of its upstream and downstream signaling molecules in solid tumors. Moreover, his focused research has also been directed toward elucidating the molecular mechanisms of action of “natural agents” and synthetic small molecules for cancer prevention and therapy. He has done a tremendous amount of work in vitro and in vivo, documenting that several “natural agents” could be useful for chemopreventive research. Most importantly, his work has led to the discovery of the role of chemopreventive agents in sensitization of cancer cells (reversal of drug-resistance) to conventional therapeutics (chemo-radiotherapy). He is one of the pioneers in developing natural agents such as Isoflavones, Curcumin and Indole compounds like DIM (B-DIM) for clinical use, and his basic science research findings led to the initiation of multiple Clinical Trials in breast, pancreas and prostate cancers at the Karmanos Cancer Institute. He is a perfect example of a true translational researcher bringing his laboratory research findings into clinical practice. Dr. Sarkar is also involved in several collaborative projects including breast, lung and pancreatic cancer for both pre-clinical and phase II clinical trials with other scientists within the institution as well as collaborative work with basic scientists and physician scientists at the MD Anderson Cancer Center. He has published over 350 original scientific articles and written more than 50 review articles and book chapters. He has been continuously funded by NCI, NIH and the Department of Defense (DOD).

Biography Updated on 16 January 2011

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