Jeffrey L. Dupree

Virginia Commonwealth University, USA

Dr. Dupree received his PhD in Anatomy and Neurobiology from Virginia Commonwealth University (Richmond, VA, USA) and was a postdoctoral fellow at the University of North Carolina (Chapel Hill, NC, USA). Following brief appointments as a junior faculty member in the Dept. of Pathology and Laboratory Medicine at the University of North Carolina and in the Dept. of Pathology and Anatomy at Eastern Virginia Medical School (Norfolk, VA, USA), Dr. Dupree joined the faculty of Virginia Commonwealth University where he is currently an Associate Professor. Dr. Dupree's research interest focus on the oligodendrocyte development, myelin synthesis and long term myelin stability particularly as these processes are involved in the maturation and maintenance of the node of Ranvier and its associated domains. Dr. Dupree's work provided some of the early evidence that proper clustering of ion channels along the axon is regulated by interactions between the myelin sheath and the axon. Moreover, Dr. Dupree showed that even subtle disruptions in the myelin-axon interface could have profound deleterious effects on node structure and function. Dr. Dupree also studies the role that myelin sphingolipids play in the development of the CNS. More recently, Dr. Dupree has begun to investigate the effect of aging on myelin structure, myelin/axon interactions and the potential increased vulnerability to CNS dysfunction consequential to aging. In addition to his own work, Dr. Dupree maintains numerous productive collaborations where he provides assistance with ultrastructural analyses. To support his work, Dr. Dupree has received funding from the National Institute of Health (USA), the National Multiple Sclerosis Society (USA), and the European Leukodystrophy Association. Dr. Dupree is also heavily involved in graduate and medical education as he teaches in his institution's graduate Neuroscience and Lipid and Membrane courses and medical Human Gross Anatomy.

Biography Updated on 4 October 2012

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