Wolfgang Neuhofer is a Heisenberg fellow of the Deutsche Forschungsgemeinschaft. He studied medicine at the Ludwig-Maximilians-Universität München and graduated in 1999; M.D. thesis in 2000, Habilitation in 2004. Since 1995, research activities at the Dept. of Physiology, LMU München. Clinical training in Internal Medicine at the Department of Medicine, Inner City Campus, LMU; Internist in 2010. Major research fields include the analysis of signal transduction pathways during osmotic stress, in particular the regulation of osmolyte-accumulating mechanisms and heat shock proteins by the osmosensitive transcription factor NFAT5 and the effect of S-nitrosylation of NFAT5 on its transcriptional activity. A further focus is on the role of NFAT5 in pro-inflammatory cytokine production. In addition to the application of common molecular biology methods, conditional knock-out of NFAT in mice is being used to advance the understanding of the mechanisms promoting cell survival in the extremely hostile environment in the renal medulla.
Biography Updated on 1 March 2012