Doriano Lamba

Istituto di Cristallografia - CNR, Trieste Outstation, Italy


Doriano Lamba obtained the Laurea degree in chemistry, 110/110 cum laude, Università degli Studi “La Sapienza”, Roma, Italy, 1980; Ph.D. degree in biophysics, University of Leeds, Leeds, UK, 1985-1988; and Postdoc at the Max Planck Institut für Biochemie, München, Germany, advisors: Prof. Dr. Robert Huber (Nobel Laureate in chemistry 1988) and Prof. Dr. Wolfram Bode, 1993-1996. Dr. Lamba served as a Member of the Management Committee of INSTRUCT (Integrated Structural Biology Infrastructure for Europe), 2008-2011; Italian Delegate of the International Network Protein Engineering Centers, since 2009; Deputy Head of Istituto di Cristallografia-CNR Trieste Outstation, Trieste, Italy, since 2010; Lecturer of structural biology at the Scuola Normale Superiore, Pisa, Italy, since 2010. He is also a Member of Italian Crystallographic Association, British Crystallographic Association, American Crystallographic Association, and Italian Biochemistry and Molecular Biology Society. His research interests include structural studies of acetylcholinesterases and their inhibitors: structure-based design of new anti-Alzheimer drugs; structural and functional studies of neutralizing antibodies (TrkA-receptor and nerve growth factor): implications for the design of novel therapeutics in neuropathic chronic pain and inflammation, Structure-based monoclonal antibodies humanization; structural and functional studies of proneurotrophins/ neurotrophins: development of painless nerve growth factor mutants; structural studies of microbial enzymes involved in polysaccharides degradation and processing: the Xylan-degrading pathway of B. pumilus in bioethanol production; and mechanistic and structural enzymology of Pseudomonas aeruginosa pathogenesis in cystic fibrosis.

Biography Updated on 6 January 2013

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