Eva C. Guinan0000-0003-3874-0007
Eva C. Guinan is a pediatric hematologist/oncologist with subspecialty expertise in marrow failure and stem cell transplantation. She graduated from Harvard College, Harvard Medical School and trained at Children's Hospital Boston and the Dana-Farber Cancer Institute. Her research has focused on identifying translational opportunities to apply biological therapies. She pioneered the use of costimulatory molecule blockade as a means of inducing alloantigen specific anergy as an application that might facilitate stem cell transplant from haploidentical family donors, an area which she continues to study. In addition, she developed the preclinical data supporting the exploration of endotoxin neutralization as a strategy to mitigate regimen-related toxicity in transplant patients, and potential other patients with mucosal barrier injury. She has been the senior investigator in studies of vaccination, venoocculsive disease treatment, and supportive care optimization in human stem cell transplantation. She is also an international expert in acquired and congenital marrow failure and has a long history of active clinical investigation in this area, particularly as regards the use of hematopoietic growth factors. After many years of directing bone marrow transplant programs, Dr. Guinan is currently the Associate Director of the Center for Clinical and Translational Research at the Dana-Farber Cancer Institute, the Medical Director of the Laboratory of Innovative Translational Technology, and Director of the Linkages Program within Clinical and Translational Science Center, Harvard Medical School.
Biography Updated on 9 November 2008