Brian Spencer

NeuroTransit, Inc., USA


I received my BS in bacteriology from the University of Wisconsin and then my PhD in Medical Microbiology and Immunology from the University of Wisconsin. My graduate work focused on preventing retinal degeneration through HSV vector mediated gene delivery of growth factors. I performed my post-doctoral training at the Salk Institute for Biological Studies in La Jolla, CA under Inder Verma. There, I developed a novel method for the transfer of proteins across the blood-brain barrier for the treatment of neurodegenerative diseases. This led to 3 patents describing various methods for delivery of proteins or genes to the CNS. Following my post-doctoral fellowship, I took a position as a project scientist at the University of California, San Diego working closely with Dr. Eliezer Masliah. At UCSD I used my approach for transporting proteins across the blood-brain barrier in the context of Alzheimer’s and Parkinson’s diseases. Recently, I founded my own company, NeuroTransit, Inc., to bring some of these Alzheimer and Parkinson therapies to the clinic. I have authored or co-authored over 30 papers in the area of neuronal therapeutics and have 3 patents in the field of neuronal therapeutics. In addition to my work in neuronal therapeutics, I have extensive experience in viral vector mediated gene delivery. At UCSD, I set up and ran the viral vector core facility in the Department of Neurosciences. With the core, we routinely cloned over expressing or shRNA expressing lentivectors as well as packaged vectors for internal and external collaborators.

Biography Updated on 1 April 2012

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