Robert A. Eisenberg

University of Pennsylvania, USA

Dr. Robert Eisenberg was educated at Haverford College and received his MD from Stanford University, where he began his research interest in Immunology in the laboratory of Dr. Irving Weissman. He trained in Internal Medicine at Cornell Medical School. He received his clinical rheumatology and further Immunology laboratory training first at the Arthritis and Rheumatism Branch of the NIH, and subsequently at the Scripps Clinic and Research Foundation in La Jolla, CA. For many years, he was on the faculty of the University of North Carolina at Chapel in the Division of Rheumatology. In 1995 he moved to the University of Pennsylvania School of Medicine to be Chief of Rheumatology until 2004. He is now Professor of Medicine and Pathology at the University of Pennsylvania. He is a member of the Association of American Physicians, American Society of Clinical Investigation, the American College of Rheumatology, the Clinical Immunology Society, the Henry Kunkel Society, and the American Association of Immunologists. Dr. Eisenberg's research interests include the cellular, biochemical, and genetic mechanisms of systemic autoimmunity, including novel therapeutic approaches. His laboratory has utilized spontaneous and experimentally induced models of systemic autoimmunty in mice in order to elucidate the cellular deficiencies in immunoregulation that are essential to this process. In the spontaneously autoimmune mouse strains, genetic defects in T and B cell tolerance are the primary abnormalities that drive the syndrome, including particularly mutations in fas or in fas ligand that impair apoptosis. The induced chronic graft-versus-host model depends on abnormal T-B interactions resulting from allogeneic recognition of major histocompatibility complex class II. Therapeutic approaches include developing models for autologous hematopoietic stem cell reconstitution and B cell depletion. The B cell targeting approaches are being applied to humans with SLE as well.

Biography Updated on 28 December 2008

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