David Murphy

University of Bristol, United Kingdom

David Murphy obtained his first degree (B.S. degree in biological sciences with first class honors in molecular biology) from the University of Edinburgh, UK, in 1979. Following a year working as a Research Technician at New York University Medical Center, he returned to the UK to pursue a Ph.D. degree in tumor virology at Imperial College, which was awarded in 1985. He was as a Postdoc with Brigid Hogan at the MRC National Institute for Medical Research in London where the focus of his research switched to neuroendocrinology, particularly the use of transgenic models to study neuropeptide gene expression and function. After a brief stint at the Royal Veterinary College in London, this work was transferred to the Institute of Molecular and Cell Biology at the National University of Singapore in 1988. Combining innovative molecular techniques, such as transgenic rat production, with physiological analysis, his group was highly productive. This effort contributed greatly to the development of the biomedical sciences and biotechnology in Singapore, both of which are now thriving. The award of a Wellcome Trust Programme Grant brought Murphy to the University of Bristol in 1996, where he is now a Professor of experimental medicine. His recent research has utilized gene identification and transfer techniques to study the neuronal regulation of homeostasis in health and disease. Moreover, his current strategies involve the use of transcriptomic and proteomic methodologies to identify genes expressed in hypothalamic and brainstem neurons, genes which alter their pattern of expression following physiological or pathological challenges (e.g., hypertension), and the use of cell-specific and inducible gene transfer methodologies in the mouse and rat (somatic and germline) to study the role of selected genes in the physiological regulation of hypothalamic and brainstem functioning in health and disease. Murphy has published over 150 papers and presently holds £4 million in grant income.

Biography Updated on 19 December 2011

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