Howard Young

Laboratory of Experimental Immunology, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, MD, USA., USA


Howard Young obtained his Ph.D. degree in microbiology from the University of Washington, Washington, DC, USA, and carried out postdoctoral research at the National Cancer Institute (NCI) under Drs. Edward Scolnick and Wade Parks. He was a Member of the Laboratory of Molecular Immunoregulation, NCI, from 1983 to 1989, prior to joining the Laboratory of Experimental Immunology in 1989. He was the President of International Society for Interferon and Cytokine Research (2004-2005) and served as the Chair of the Immunology Division of the American Society for Microbiology. He has also served as the Chair of the NIH Cytokine Interest Group and Cochair of the NIH Immunology Interest Group. He is a two-time recipient of the NIH Director's Award for Mentoring (2000, 2006) and in 2006 he received the National Public Service Award. In 2007 he was named Deputy Chief, Laboratory of Experimental Immunology. The general goals of the laboratory are to use cellular and molecular approaches to investigate the consequences of persistent exposure to IFN-gamma on immune system development, maturation, and function. To approach this question, we have generated a novel mouse model where a portion of the 3' untranslated region of the mRNA has been changed resulting in a much more stable IFN-g mRNA. These mice are characterized by low but chronic interferon-gamma expression. As a result there is persistent upregulation of IFN-gamma inducible genes, resulting in the development of autoimmunity. Our studies provide a basis for developing a more complete understanding of the effects of IFN-g expression during the pathogenesis of autoimmune disease, cancer, and infection.

Biography Updated on 27 September 2014

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