Arnab K. Chatterjee

Genomics Institute of the Novartis Research Foundation, USA

Arnab Kumar Chatterjee was born in Calcutta, India in 1975. After completing a Bachelor of Arts in Chemistry and minor in Business from Northwestern University in 1997, he proceeded on to the California Institute of Technology in October 1998 to conduct his doctoral thesis research in the laboratory of Professor Robert H. Grubbs in the Division of Chemistry and Chemical Engineering. His doctoral research focused on understanding the reactivity and selectivity patterns of olefin cross-metathesis reactions using catalytic ruthenium alkylidenes. He also discovered previously unprecedented formation of trisubstituted olefins andunsaturated olefins by intermolecular olefin metathesis chemistry, greatly expanding the olefin cross-metathesis methodology. Subsequently, Professor Robert H. Grubbs was awarded the Nobel Prize in Chemistry in 2005 for his work in the area olefin metathesis. Upon completion of his doctoral research in September 2002, Arnab joined the Genomics Institute of the Novartis Research Foundation as a principal investigator in the chemistry department. His work over the last 8+ years has been focused on hit-to-lead and lead optimization in several medicinal chemistry projects ranging a variety of therapeutic areas (neuroscience, oncology, respiratory disease and infectious diseases). The project teams he has worked with have produced 3 preclinical candidates optimization for both inhaled and oral formulations. Recently, Arnab has lead a hit-to-lead and lead optimization programs for infectious diseases and progressed screening hits to compound that demonstrate in vivo efficacy similar to current front-line medications. Arnab’s research interests include application of novel synthetic methods to expedite the structural diversification in medicinal chemistry and cell-based lead optimization.

Biography Updated on 24 November 2010

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