Pierre Vierling

Université de Nice-Sophia Antipolis, France

Pierre Vierling received a 3ème Cycle Doctorat from the University Louis Pasteur, Strasbourg, France (1978), and Doctorat ès-Sciences Physiques from the University of Nice Sophia Antipolis (UNS), Nice, France (1983) under the supervision of Professor J.-M. Lehn. Vierling won the Nobel Prize in chemistry in 1987. Currently, he serves as a First-Class Research Director at CNRS, Institut de Chimie de Nice, UMR 7272 CNRS-UNS, Parc Valrose, Cedex 2, Nice, France. Since 1992, the scientific interests of Vierling are mainly focused on the development of drug (including conventional drugs or genes) delivery systems for therapy, with a particular interest for highly fluorinated systems and for “artificial viruses.” These activities have led to the synthesis of various vectors (fluorinated cationic lipids, helper lipids, cationic detergents, and polycationic hetero(homo)(co)polymers) specifically aimed at the compaction of genes into nanoparticles (lipoplexes and polyplexes) of various labelled conjugates (glycolipids and cationic galacto-bolaamphiphiles) for the specific delivery to targeted cells, of DNA-intercalating NLS peptide conjugates for improving the intracellular traffic of DNA to the nucleus, and of various fluorinated phospholipids for the formulation of fluorinated liposomes. Besides strong skills in organic synthesis, Vierling has also a strong expertise in formulation, characterization of nanodevices, in drug encapsulation, and in vitro biological evaluations of the gene transfer mediated by synthetic vectors into various cells. Presently, the team comprises one CNRS researchers, two assistant professors, one postdoctoral fellow, and one Ph.D. student. Vierling coauthored more than 110 publications, 7 reviews, 8 patents, and supervised 23 Ph.D. dissertations. His areas of expertise include medicinal chemistry, bioorganic chemistry, prodrugs, antivirals, drug delivery, gene transfer, synthetic viruses, and nano(bio)technology.

Biography Updated on 28 November 2012

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