N. Hattori received his M.D. degree from Juntendo University in 1985. He became a resident at the Department of Neurology of Juntendo Hospital. After finishing residency training in Juntendo Hospital, he was appointed as an Assistant Professor of neurology at Juntendo University, Tokyo, Japan, in 1988. He was certified by Japanese Neurological Society in 1989. He admitted to a graduate school of Juntendo University in 1990. Dr. Hattori was trained for molecular biology at Department of Biomedical Chemistry of Nagoya University from 1990 to 1993. Then, he was appointed as an Assistant Professor of neurology at Juntendo University School of Medicine in 1995, and then became an Associate Professor of neurology in 2003. Finally, he became a Professor and a Chairman at Juntendo University School of Medicine in 2006. He is an Active Member of Japanese Neurological Association and a Corresponding Member of the American Neurological Association. He is also a Member of Movement Disorders Society. He serves as an Ad Hoc Reviewer of many international journals and has been interested in the etiology and pathogenesis of Parkinson’s disease. He found decrease in the amount of complex I in the substantia nigra of Parkinson’s disease patients. More recently, he and his collaborators identified the disease gene for an autosomal recessive form of young onset familial Parkinson’s disease, and named the gene as “parkin”. This is the second form of familial Parkinson’s disease in which the disease gene was identified. In addition, he and his collaborators found that the gene product, parkin is direct linked to ubiquitin-proteasome pathway as an ubiquitin ligase. This discovery suggested that protein degradation system is involved in the pathogenesis of not only monogenically Parkinson’s disease but also sporadic Parkinson’s disease.
Biography Updated on 2 March 2011