Rodrigo A. Fuentealba

Laboratory of Cellular and Molecular Immunology, Faculty of Medicine, Universidad de los Andes, Chile

0000-0001-8724-091X

Recent studies have shown that, besides its extensive use in regenerative medicine, mesenchymal stem cells (MSC)also play a regulatory role in the immunological system. My research aims to understand molecular mechanisms behind the MSC-mediated inhibition of the immune system. Particularly, we are interested in defining a role for the neurotransmitter GABA in the immunomodulatory role of MSC. We have hypothesized that GABAergic signaling promotes (1) inhibition of proinflammatory T helper lymphocytes, and (2) increase of immunosuppressive, regulatory T cells. Furthermore, we are currently investigating gene expression regulation for the GABA biosynthetic enzyme GAD and for GABA receptor subunits in T cells and MSC. The establishment of active GABA signaling in the immune system will allow us to explore new cell-based therapies using MSC and GAD for autoimmune diseases.

Biography Updated on 3 March 2015

Scholarly Contributions [Data Provided by ]

download