Margaret S. Bynoe

Cornell University Veterinary Medical College, USA

Dr. Margaret Bynoe, an Associate Professor in the Department of Immunology and Infectious Diseases, received her Bachelor of Science degree in Biology from Long Island University in 1991. She received her PhD from Albert Einstein College of Medicine in 1999 where she studied the molecular basis of steroid hormones in the development of the autoimmune disease systemic lupus erythematosus. She received her postdoctoral training in the laboratory of Charles A Janeway, Jr. where she studied the immunological bases of Type1 Diabetes and multiple sclerosis (MS) and later became an Associate Research Scientist at Yale University School of Medicine. In her current position as an Associate Professor at Cornell University, Dr. Bynoe’s work encompasses studies in autoimmunity, regulation of inflammation both systemically and in the central nervous system. She also studies mobilization of the immune response to recognize and attack tumors and prevention of tumor recurrence by induction of a memory response. Work in her lab includes studies of the regulation of gut inflammation, using models of inflammatory bowel diseases and studies on the immune pathogenesis of multiple sclerosis (MS) in experimental autoimmune encephalomyelitis (EAE), the animal model for MS. She also studies the impact of inflammation (chronic and acute) on the pathogenesis and acceleration of Alzheimer’s disease (AD) in an AD transgenic mouse model, and of the regulation of molecules such as adenosine, a purine nucleoside that is a master regulator of immune responses in addition to its other roles in host physiology. Finally, a major area of Dr. Bynoe’s work is centered around regulation of central nervous system barriers and their impact on neurological diseases such as Alzheimer’s and MS.

Biography Updated on 21 May 2012

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