Maria Paula Macedo

Universidade Nova de Lisboa, Portugal


Maria Paula Macedo graduated in pharmacy from the Faculty of Pharmacy at the University of Lisbon (Lisbon, Portugal) in 1989 and received her Ph.D. degree in 1996 from the Department of Pharmacology and Therapeutics at the University of Manitoba (Winnipeg, Canada). She was appointed as Professor of pharmacology for pharmacy at the Institute of Health Sciences (Portugal). Since 2000 she has served as Professor of physiology at the Faculty of Medical Sciences at the Nova University of Lisbon. Dr. Macedo has been working in research areas related to hepatic vasculature and hepatic control of insulin sensitivity. In life sciences, she has been awarded several grants as a principal investigator including topics such as the study of meal-induced insulin action and the dysfunction of this potentiation in prediabetes and in related to diabetes as well as the clarification of the molecular mechanisms involved; assessment of subclinical impairments of the autonomic nervous system with impact on glucose and lipid metabolisms; modulation of hepatic inflammatory responses that induce whole-body insulin resistance, targeting Kupffer cells, and nitric oxide production; physiological and pathophysiological alterations of insulin clearance; in vitro studies with skeletal muscle looking at glucose uptake under mimicked controlled or unregulated metabolic conditions; application of environmental and genetic pathological animal models; mathematical modeling of insulin secretion, insulin clearance, and overall glucose fluxes; and the first prevalence study of prediabetes and diabetes in Portugal. She was awarded in recognition of science from the Canadian Pharmacological Society, Western Pharmacological Society, Portuguese Diabetes Association, and APDP-Diabetes Portugal. She is actively involved in promotion diabetes research in Portugal by heading the Grupo de Investigação Fundamental e Translacional (GIFT) of the Portuguese Diabetes Association.

Biography Updated on 11 November 2014

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